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Dr. Hansen’ lab studies the interactions between satellite cells and the vasculature. Satellite cells are skeletal muscle progenitor cells that are known to play an important role in muscle repair after injury and adaptation to exercise. However, the Hansen lab focuses on a previously underexplored role of satellite cells in vascular growth. They have found that satellite cells, when activated, produced a number of chemoattractant growth factors that drive the migration of vascular smooth muscle and endothelial cells which in an important factor in the growth and development of blood vessels. This area is of particular interest in the context of peripheral artery disease (PAD), where patients suffer from ischemic tissue damage but treatment options are still limited. We have found that the effectiveness of exercise therapy in PAD is related to satellite cell. We are currently using single cell sequencing techniques to explore satellite cell biology in the context of exercise with the hope of development more optimal exercise regimens.
This position would be focused on studying satellite cell heterogeneity and transcriptional regulation in response to exercise therapy. The project will utilize mouse models of vascular growth, satellite cell ablation, and running as well biopsies from PAD patients undergoing exercise therapy. Tasks will include animal model, cell isolation and sorting, single cell sequencing, and computational analysis using R and other software to determine parameters such as cell clusters and pathway enrichment networks.
MINIMUM QUALIFICATIONS: A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS etc) in an appropriate field. Excellent scientific writing ability and strong oral communication skills. The ability to work effectively and collegially with colleagues. Additional qualifications as specified by the Principal Investigator.
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