JOB DESCRIPTION: Helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career. The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc. Designs and evaluates experiments. Develops new ideas that promote current research. Prepares and publishes scientific manuscripts under the direction of the Principal Investigator. May be responsible for operation of specific equipment. May teach techniques to others, train, and supervise research staff. Positions are temporary appointments as a research trainee. The initial appointment is for one year, renewal expected if progress is satisfactory and funds are available. Appointments cannot exceed five years.
MINIMUM QUALIFICATIONS: A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS etc) in an appropriate field. Excellent scientific writing ability and strong oral communication skills. The ability to work effectively and collegially with colleagues. Additional qualifications as specified by the Principal Investigator.
A funded postdoctoral fellowship position is available in the Kukar Lab at Emory University in the Department of Pharmacology and Neurology and the Center for Neurodegenerative Diseases. The Kukar lab uses a multi-disciplinary approach spanning molecular neuroscience, chemical biology, biochemistry, bioinformatics, iPSCs, and mouse models to investigate the mechanisms of neurodegeneration. A major focus is to study how autophagy/lysosome dysfunction and neuroinflammation interact to cause Frontotemporal Dementia or Alzheimer’s disease.
This project builds upon our recent paper (Holler et al, eNeuro, 2017) to understand how decreases in the Progranulin protein causes lysosome dysfunction and ultimately neurodegeneration. Major goals are to 1) investigate the molecular mechanisms of lysosomal dysfunction and inflammation caused by GRN mutations and 2) use gene therapy approaches (Adeno-Associated Virus) to test a novel therapeutic approach to treat FTD caused by GRN mutations.”
A Recent Ph.D. or M.D./Ph.D. in a relevant field (i.e. neuroscience, cell biology, immunology, biochemistry, neuroscience). A track-record of publications and excellent written/verbal communication skills. A background in neuroscience and neurodegeneration is preferred. Experience in molecular biology, biochemistry, cell culture, transgenic animal models, animal surgery, CRISPR/Cas9 techniques, proteomics or human iPSC modeling is a plus, but not required. Fellows are expected to co-author manuscripts, collaborate with lab members, and contribute to the training and management of new lab recruits.