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Few medical therapies are available for patients with small bowel neuroendocrine tumors (SBNETs) and the existing options are not very effective at eliminating the cancer. Our goal is to investigate the mechanism of drug resistance in SBNETs. We aim to determine the expression of NRF2 in SBNET tissue microarrays in comparison to other NETs. We will genetically modulate NRF2 activity by performing NRF2 and KEAP1 Knockout and test for drug sensitivity in vitro and in vivo models. In addition, we will characterize the interaction between NRF2 and its binding partner in patient-derived SBNET spheroids.
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