JOB DESCRIPTION: Helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career. The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc. Designs and evaluates experiments. Develops new ideas that promote current research. Prepares and publishes scientific manuscripts under the direction of the Principal Investigator. May be responsible for operation of specific equipment. May teach techniques to others, train, and supervise research staff. Positions are temporary appointments as a research trainee. The initial appointment is for one year, renewal expected if progress is satisfactory and funds are available. Appointments cannot exceed five years.
MINIMUM QUALIFICATIONS: A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS etc) in an appropriate field. Excellent scientific writing ability and strong oral communication skills. The ability to work effectively and collegially with colleagues. Additional qualifications as specified by the Principal Investigator.
The Ghosn lab is looking to recruit a postdoctoral fellow interested in examining the development and function of the mammalian immune system at a single-cell level. In the long run, our goal is to understand the differences between the immune cells that develop in fetal, neonatal, and adult life, and determine the functional impact of these differences in promoting host immunity or immunopathology.
Our studies employ and drive the frontiers of high-dimensional (18+ parameter) flow cytometry technologies to isolate, characterize, and transplant single immune and stem cells from both fetal and adult sources. Recently, we have identified, in mouse models, lineages of innate-like tissue-resident B lymphocytes and macrophages that develop in the fetus, independently of fetal and adult hematopoietic stem cells. We are also using humanized mice to investigate the development and function of these innate-like tissue-resident B lymphocytes in humans during both infancy and adulthood.
Candidates should have a Ph.D. in Immunology, Biology, Molecular Biology, or a related field, and have research experience using mouse models, primary cells, and common cellular and molecular immunology assays.
The fellow will receive advanced training in high-dimensional (18+ parameter) flow cytometry techniques and participate in research at the frontier of this and related technologies, including high-throughput single cell-based gene expression assays (HT-qPCR and RNA/BCR sequencing).
Experience with high-dimensional flow cytometry and/or single-cell transcriptomics would be a plus.